Effects of innate immune stimulation on naturally occurring respiratory disease in beef calves

Authors

  • E. I. Kaufman Department of Pathobiology, Ontario Veterinary College, SO Stone Road East, Guelph, ON, N1G2W1, Canada
  • L. L. Bassel Department of Pathobiology, Ontario Veterinary College, SO Stone Road East, Guelph, ON, N1G2W1, Canada
  • S. N. A. Alsop Department of Pathobiology, Ontario Veterinary College, SO Stone Road East, Guelph, ON, N1G2W1, Canada
  • K. Vulikh Department of Pathobiology, Ontario Veterinary College, SO Stone Road East, Guelph, ON, N1G2W1, Canada
  • L. R. Siracusa Department of Pathobiology, Ontario Veterinary College, SO Stone Road East, Guelph, ON, N1G2W1, Canada
  • J. Hewson Department of Clinical Studies, Ontario Veterinary College, SO Stone Road East, Guelph, ON, N1G2W1, Canada
  • S. Sharif Department of Pathobiology, Ontario Veterinary College, SO Stone Road East, Guelph, ON, N1G2W1, Canada
  • J. L. Caswell 1Department of Pathobiology, Ontario Veterinary College, SO Stone Road East, Guelph, ON, N1G2W1, Canada

DOI:

https://doi.org/10.21423/aabppro20183210

Keywords:

immunosuppression, bovine respiratory disease, BRD, feedlot calves, innate immune response, beef cattle

Abstract

Stress- and virus-induced immunosuppression are considered major risk factors for the development of bovine respiratory disease (BRD) in beef calves. Although vaccines and the metaphylactic use of antibiotics are available to minimize BRD in herds, it continues to be the leading cause of morbidity in feedlot calves. Research in mice found that lethal bacterial pneumonia was prevented by stimulating the innate immune system. The purpose of this study was to determine if stimulation of innate immune responses on arrival to a feedlot could decrease the prevalence and severity of naturally occurring BRD in beef calves.

Cover image of the 51st Conference Proceedings: A man riding on a pale horse herding cattle on a semi-arid pasture

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Published

2018-09-13

Issue

2018

Section

Research Summaries