Efficacy of a combination butaphosphan-cyanocobalamin product and insulin for the treatment of ketosis in lactating dairy cattle

Authors

  • J. L. Gordon Population Medicine, University of Guelph, Guelph, Ontario, N1G 2W1
  • T. F. Duffield Population Medicine, University of Guelph, Guelph, Ontario, N1G 2W1
  • T. Herdt Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824
  • L. Neuder Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824
  • D. F. Kelton Population Medicine, University of Guelph, Guelph, Ontario, N1G 2W1
  • S. J. LeBlanc Population Medicine, University of Guelph, Guelph, Ontario, N1G 2W1

DOI:

https://doi.org/10.21423/aabppro20123916

Keywords:

postpartum, negative energy balance, ketones, β-hydroxybutyrate, BHBA, Insulin, medications, butaphosphan-cyanocobalamin

Abstract

In the early postpartum period, negative energy balance is nearly ubiquitous in dairy cattle. During this period, excessive ketones, generally measured as β-hydroxybutyrate (BHBA), are associated with lower milk production, increased risk of concurrent diseases, and decreased reproductive performance. Insulin has been recommended for the treatment of ketosis because of its anabolic effects. It has been hypothesized that administration of vitamin B12 (cyanocobalamin) may increase gluconeogenesis by increasing the activity of methylmalonyl-CoA mutase, a vitamin Bl2-dependent enzyme and important component of the Krebs or tricarboxylic acid (TCA) cycle. Recent studies have shown that a combination butaphosphan-cyanocobalamin product (B+C; Catosal®, Bayer Animal Health) is efficacious for the prevention of ketosis when it is administered at calving. However, neither of these medications has been studied for efficacy in the treatment of ketosis in North American dairy cattle under commercial conditions. The objective of this study was to determine the efficacy of a butaphosphan-cyanocobalamin combination product and insulin on ketosis cure rates and BHBA concentrations.

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Published

2012-09-20

Issue

Section

Research Summaries 2

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