Glucose Transporter Expression in Bovine Monocytes

Authors

  • Nial J. O'Boyle Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824
  • Andres Contreras Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824
  • Sarah Matmiller Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824
  • Lorraine Sordillo Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824

DOI:

https://doi.org/10.21423/aabppro20114027

Keywords:

mammary gland, glucose, periparturient, macrophages, glucose transporter expression, bovine monocytes, GLUT, lactogenesis

Abstract

The transition from involution of the mammary gland to lactation exerts substantial glucose demands on the dairy cow to support copious milk synthesis and secretion. Immune dysfunction also occurs at this time, with a concurrent high incidence of periparturient disorders. Macrophages are known to increase during the periparturient period and to have enhanced inflammatory properties. Little is known, however, about how the prioritization of glucose towards the mammary gland affects glucose uptake by macrophages. The objective of this study was to identify glucose transporter expression (GLUT) in bovine monocytes and examine how they alter during lactogenesis and following stimulation with endotoxin.

Cover image of the 44th Conference Proceedings: photo of the skyline of St. Louis, Missouri, site of the 2011 AABP Conference. Yellow background.

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Published

2011-09-22

Issue

2011

Section

Research Summaries 2