Impact of Ceftiofur Use on the Recovery of Salmonella and Resistant E. coli in Dairy and Beef Cattle Populations

Authors

  • K. E. Kleinhenz Veterinary Preventive Medicine, The Ohio State University, Columbus, OH 43210
  • D. F. Mollenkopf Veterinary Preventive Medicine, The Ohio State University, Columbus, OH 43210
  • L. C. Heider Veterinary Preventive Medicine, The Ohio State University, Columbus, OH 43210
  • J. A. Funk Large Animal Clinical, Michigan State University, East Lansing, MI 48824
  • T. E. Wittum Veterinary Preventive Medicine, The Ohio State University, Columbus, OH 43210

DOI:

https://doi.org/10.21423/aabppro20104152

Keywords:

cephalosporin, ceftiofur, blaCMY-2, intestinal flora, resistant organism, food animal, zoonotic pathogen

Abstract

The use of the third generation cephalosporin, ceftiofur, is common in animal agriculture for the treatment of a wide range of production-limiting disease conditions. The therapeutic use of ceftiofur in livestock can select for the blaCMY-2 genetic element in the intestinal flora. The presence of resistant organisms is a potential public health threat to the consumer. This project investigated the impact of ceftiofur removal from cattle populations and the meat products they produced.

The working hypothesis is that the use of ceftiofur in food animal populations selects for the emergence and rapid dissemination of third generation cephalosporin resistant microorganisms, leading to the potential risk of food-borne zoonotic pathogen transfer via the food chain.

Cover image of the 43rd Conference Proceedings: Two short-horned cattle grazing in a field, surrounded by a flock of egrets. Yellow background.

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Published

2010-08-19

Issue

2010

Section

Research Summaries 4

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