Apparent Differences in Xylazine, Ketamine, and Butorphanol Pharmacokinetics Linked with Pain Associated with Dehorning and Castration

Authors

  • J. F. Coetzee Veterinary Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506
  • R. Gehring Veterinary Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506
  • S. Barron Veterinary Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506
  • D. E. Anderson Veterinary Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506
  • J. Havel PharmCATS Bioanalytical Services, Kansas State University, Manhattan, KS 66502

DOI:

https://doi.org/10.21423/aabppro20094325

Keywords:

castration, dehorning, pain management, peripheral vasoconstriction, heart rate, pharmacokinetics, sedative-analgesics

Abstract

Management of pain following dehorning and castration is a significant challenge for veterinarians. Physiological effects such as peripheral vasoconstriction and increased heart rate are associated with pain and distress. These effects may alter the pharmacokinetics of parenterally administered sedative-analgesics.

Cover image of the 42nd Conference Proceedings: Cattle grazing in a spring field along the horizon. In the foreground, one brown cow with a triangle marking and ear tags is posing. Yellow background.

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Published

2009-09-10

Issue

2009

Section

Research Summaries 3

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