Comparison of Three Oral Chlortetracycline Treatment Regimens for Persistent Anaplasma marginale Carrier Clearance

Authors

  • J. B. Reinbold Department of Veterinary Clinical Sciences; Kansas State University, Manhattan, KS 66506
  • J. Coetzee Department of Veterinary Clinical Sciences; Kansas State University, Manhattan, KS 66506
  • L. Hollis Department of Animal Sciences & Industry; Kansas State University, Manhattan, KS 66506
  • C. Wood Department of Animal Sciences & Industry; Kansas State University, Manhattan, KS 66506
  • K. C. Olson Department of Animal Sciences & Industry; Kansas State University, Manhattan, KS 66506
  • R. Ganta Department of Diagnostic Medicine I Pathobiolology; Kansas State University, Manhattan, KS 66506

DOI:

https://doi.org/10.21423/aabppro20084401

Keywords:

Anaplasma marginale, tick-transmitted disease, chlortetracycline, oral treatments, persistently infected

Abstract

Anaplasma marginale causes the most prevalent tick-transmitted disease of cattle. Once infected, a lifelong carrier state persists to function as a disease reservoir enabling subsequent vector infection or production equipment contamination. Despite reports of successful carrier clearance, no antimicrobial compound is labeled for disease elimination. In the absence of an efficacious vaccine, a validated antimicrobial regimen for persistent A. marginale elimination is urgently needed. Three oral chlortetracycline (CTC) treatments were evaluated for carrier clearance in cattle persistently infected with a Virginia isolate of A marginale.

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Published

2008-09-25

Issue

Section

Research Summaries