Efficacy of a Combination Modified-Live Viral Vaccine in Protecting Cattle from Experimental Infection with Bovine Herpesviruses-1 isolated from Recent "Vaccine Breaks"

Authors

  • J. Ellis Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada
  • S. Gow Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada
  • N. Goji Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada
  • C. Jones Department of Veterinary Science, University of Nebraska, Lincoln, NE
  • C. Rhodes Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada

DOI:

https://doi.org/10.21423/aabppro20084436

Keywords:

vaccine breaks, bovine herpesvirus-1, BHV-1, feedlot cattle, field isolates, beef calves

Abstract

In recent years there has been a reported increase in "vaccine breaks", or apparent failure of bovine herpesvirus-1 (BHV-1) vaccines to protect feedlot cattle. In order to address the possibility that current vaccines derived from the Cooper isolate of BHV-1 do not protect calves from infection with recent virulent field isolates of BHV-1 for weeks or months after vaccination, two randomized controlled trials were conducted in BHV-1 seronegative cross-bred beef calves.

Cover image of the 41st Conference Proceedings: A herd of cattle standing in the field, framed by a cloudy sky. Yellow background.

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Published

2008-09-25

Issue

2008

Section

Research Summaries