Relationship of Body Condition Score and Oxidant Stress on Tumor Necrosis Factor Expression in Dairy Cattle

Authors

  • N. J. O'Boyle Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI
  • C. Corl Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI
  • J. Gandy Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI
  • L. M. Sordillo Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI

DOI:

https://doi.org/10.21423/aabppro20064734

Keywords:

mobilization of body fat, pro-inflammatory cytokines, pro-inflammatory environment, oxidative damage

Abstract

Excessive mobilization of body fat in the dairy cow is a well-known risk factor for poor fertility, metabolic problems and increased susceptibility to a variety of infectious diseases. In humans, obese patients have an enhanced production of pro-inflammatory cytokines (such as Tumor Necrosis Factor-alpha and Interleukin- 6), which has been recognized to induce a pro-inflammatory environment and facilitate oxidative damage, leading to the initiation and progression of an array of diseases. The purpose of this study was to investigate if a similar relationship exists in the dairy cow between obesity, oxidative stress, pro-inflammatory cytokines and susceptibility to disease.

Cover image of the 39th Conference Proceedings: Three calves lying down in a pasture next to a white fence. Behind them, a rainbow spans over the distant hills. Yellow background.

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Published

2006-09-21

Issue

2006

Section

Research Summaries 2

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