Fetal Protection Against Continuous Exposure To Bovine Viral Diarrhea Virus Following Administration of A Vaccine Containing an Inactivated BVDV Fraction

Authors

  • Daniel L. Grooms Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824
  • Steven R. Bolin Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824
  • Paul H. Coe Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824
  • Rafael Borges Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824
  • Christopher E. Coutu Pfizer Animal Health, Kalamazoo, MI 49001

DOI:

https://doi.org/10.21423/aabppro20064753

Keywords:

Bovine viral diarrhea virus, BVDV, economic loss, persistent infection, viremia, fetal infection

Abstract

Bovine viral diarrhea virus (BVDV) is a major viral pathogen of cattle, leading to substantial economic losses. A major source of loss is attributed to fetal infection with subsequent fetal pathology. The major source of virus transmission is cattle that are immunotolerant and persistently infected with BVDV. The objective of this study was to determine if a commercially available killed BVDV vaccine (CattleMasterR® Gold TM FP™ L5, Pfizer Animal Health) could protect cattle against viremia and fetal infection during continuous exposure to cattle persistently infected with the BVDV. This type of model may more closely represent natural challenge, including continuous exposure to multiple virus strains.

Cover image of the 39th Conference Proceedings: Three calves lying down in a pasture next to a white fence. Behind them, a rainbow spans over the distant hills. Yellow background.

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Published

2006-09-21

Issue

2006

Section

Research Summaries 3