Effect of Genistein on Bovine Herpes virus 1 Infections In vivo

Authors

  • Lyle Braun Department of Veterinary Science, South Dakota State University, Brookings, SD 57007
  • Mark Braunschmidt Department of Veterinary Science, South Dakota State University, Brookings, SD 57007
  • Nicholas Arias Department of Veterinary Science, South Dakota State University, Brookings, SD 57007
  • Regina L. Wixon Department of Nutrition and Food Science, South Dakota State University, Brookings, SD 57007
  • Chungyang Wang Department of Nutrition and Food Science, South Dakota State University, Brookings, SD 57007
  • Christopher C. L. Chase Department of Veterinary Science, South Dakota State University, Brookings, SD 57007

DOI:

https://doi.org/10.21423/aabppro20025066

Keywords:

natural antivirals, shipping, stressors, bovine respiratory disease complex, genistein

Abstract

Finding natural antivirals to feed to cattle in their receiving diets following shipping and other stressors is important to help limit bovine respiratory disease complex (shipping fever). Previously, we had demonstrated that bovine cells treated with the naturally occurring soya isoflavone, genistein, produced 10-1000 times less virus than untreated cells. In this study, we established a level of genistein to treat calves with in vivo and then challenged them with bovine herpesvirus 1 (BHV-1; IBR). Calves that received genistein produced as much virus but shed virus for a shorter period of time and also had less severe clinical signs.

Cover image of the 35th Conference Proceedings: Holstein cows standing in a row at a fence. A small group of cattle are bunched together in a pen. Yellow background.

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Published

2002-09-26

Issue

2002

Section

Research Summaries - General

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