Variance in Response to Vaccination of Dairy Cows with Recombinant Arcanobacterium pyogenes pyolysin, by Breed
DOI:
https://doi.org/10.21423/aabppro20025079Keywords:
vaccination, recombinant pyolysin, A. pyogenes, mastitisAbstract
Arcanobacterium pyogenes is a common inhabitant of the mucous membranes of dairy cattle. This organism is an opportunistic pathogen, associated with suppurative infections of the skin, joints and visceral organs, as well as abortion and mastitis. A. pyogenes secretes pyolysin, a hemolytic exotoxin which is both an important virulence factor and a host protective antigen. The object of this study was to determine whether vaccination of dairy cows with recombinant pyolysin would result in production of a neutralizing antibody response against pyolysin, with the ultimate goal of designing a vaccine against A. pyogenes mastitis. Brown Swiss and Holstein cows were included in the vaccination trial, to determine whether breed influenced response to the vaccine.