Variance in Response to Vaccination of Dairy Cows with Recombinant Arcanobacterium pyogenes pyolysin, by Breed

Authors

  • S. Peder Cuneo Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85705
  • Dusti J. Pruna Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85705
  • Stephen J. Billington Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85705
  • J. Glenn Songer Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85705
  • B. Helen Jost Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85705

DOI:

https://doi.org/10.21423/aabppro20025079

Keywords:

vaccination, recombinant pyolysin, A. pyogenes, mastitis

Abstract

Arcanobacterium pyogenes is a common inhabitant of the mucous membranes of dairy cattle. This organism is an opportunistic pathogen, associated with suppurative infections of the skin, joints and visceral organs, as well as abortion and mastitis. A. pyogenes secretes pyolysin, a hemolytic exotoxin which is both an important virulence factor and a host protective antigen. The object of this study was to determine whether vaccination of dairy cows with recombinant pyolysin would result in production of a neutralizing antibody response against pyolysin, with the ultimate goal of designing a vaccine against A. pyogenes mastitis. Brown Swiss and Holstein cows were included in the vaccination trial, to determine whether breed influenced response to the vaccine.

Cover image of the 35th Conference Proceedings: Holstein cows standing in a row at a fence. A small group of cattle are bunched together in a pen. Yellow background.

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Published

2002-09-26

Issue

2002

Section

Posters