Fallibility of Measurement of Strong Ion Difference for Evaluation of Acid-base Status in Diarrheic Calves
DOI:
https://doi.org/10.21423/aabppro19995544Keywords:
Acid base balance, Strong Ion Difference, calf diarrhea, naturally occurringAbstract
Acid base balance has traditionally been described in terms of the Henderson-Hasselbach equation (pH, pCO2 , TCO2). Strong Ion Difference (SID= Na++ K+ - Cl-) is a recent concept and purports to better describe and explain the mechanisms involved in acid base physiology.1,2 Quantitative acid-base analysis utilizing the measurement of SID does not appear to have been utilized to any significant extent in human medicine3,4 although it appears to be gaining credence in both clinical and experimental veterinary medicine as a means of describing acid-base status.5 The objective of this study was to evaluate measurement of SID as a means of diagnosing and quantifying acid-base disturbances in naturally occurring cases of calf diarrhea.