Development of a Model for Use in Pharmaceutical Trials

Induced Pasteurella Pneumonia and Body Temperature Telemetry in Weaned Beef Calves

Authors

  • Virginia R. Fajt Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University 1714 Vet Med, Ames, IA 50011-1250
  • Michael D. Apley Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 1722 Vet Med, Ames, IA 50011-1250
  • Kim A. Brogden National Animal Disease Center, USDA-ARS, P.O. Box 70, Ames, IA 50010
  • Terry Skogerboe Clinical Development, Pfizer Animal Health, One Pfizer Way, Lee's Summit, MO 64081-2998

DOI:

https://doi.org/10.21423/aabppro19995560

Keywords:

pneumonia induction, body temperature, lung consolidation, neutrophil function, antimicrobial therapies

Abstract

The most common method for inducing pneumonic
pasteurellosis in cattle for the study of therapeutic and
immunologic interventions is to instill fresh live cultures
of Pasteurella haemolytica into the trachea, into main
stem bronchi, or into the thoracic cavity percutaneously
(transthoracic). Evaluating therapeutic outcome may include
comparisons of clinical recovery, mortality, weight
gain, or other response variables.

Our initial efforts to induce pneumonia in beef calves utilizing a model previously validated in neonatal dairy calves produced inconsistent results. In order to use the model in pharmacotherapeutic trials, disease must be reliably produced. We were interested in developing a model for induction of pneumonia in weaned beef calves (approximately 400 lbs.) so that differences in body temperature, lung consolidation and neutrophil function could be used to compare antimicrobial therapies.

Cover image of the 33rd Conference Proceedings: Herd of Holstein cattle grazing in a field. Large barn and silos in background. Yellow background.

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Published

1999-09-23

Issue

1999

Section

Research Summaries 2

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