Pasteurella haemolytica Vaccines and Their Effectiveness

Authors

  • Raymond W. Loan Department of Veterinary Pathobiology, Texas A&M University
  • Charles W. M. Purdy USDA Conservation and Production Research Laboratory, Bushland, Texas

DOI:

https://doi.org/10.21423/aabppro19956162

Keywords:

Pasteurella haemolytica, immune response, Bacterin-toxoid vaccine, inoculation, formulations, intramuscular, subcutaneous

Abstract

Pasteurella haemolytica biotype A, serotype 1 (Ph1) bacterins and bacterin-toxoids formulated in oil adjuvants induce protective immune responses approaching those induced by virulent Ph1. In comparison, aluminum hydroxide based adjuvants induce lower protective and serological immune responses. Bacterin-toxoid vaccines formulated in water-in-oil adjuvants induced high levels of protective immunity against transthoracic and field challenge. Bacterin-toxoid with oil-in-water adjuvant induced high protective immunity against transthoracic challenge and was superior to Ph1 bacterin-toxoid withAI(OH)3 adjuvant. Reactions at the point of inoculation vary with formulations, are usually inapparent if intramuscular, manageable if subcutaneous and disappear with time.

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Published

1995-09-14

Issue

Section

Research Summaries 1