Pasteurella haemolytica Vaccines and Their Effectiveness

Authors

  • Raymond W. Loan Department of Veterinary Pathobiology, Texas A&M University
  • Charles W. M. Purdy USDA Conservation and Production Research Laboratory, Bushland, Texas

DOI:

https://doi.org/10.21423/aabppro19956162

Keywords:

Pasteurella haemolytica, immune response, Bacterin-toxoid vaccine, inoculation, formulations, intramuscular, subcutaneous

Abstract

Pasteurella haemolytica biotype A, serotype 1 (Ph1) bacterins and bacterin-toxoids formulated in oil adjuvants induce protective immune responses approaching those induced by virulent Ph1. In comparison, aluminum hydroxide based adjuvants induce lower protective and serological immune responses. Bacterin-toxoid vaccines formulated in water-in-oil adjuvants induced high levels of protective immunity against transthoracic and field challenge. Bacterin-toxoid with oil-in-water adjuvant induced high protective immunity against transthoracic challenge and was superior to Ph1 bacterin-toxoid withAI(OH)3 adjuvant. Reactions at the point of inoculation vary with formulations, are usually inapparent if intramuscular, manageable if subcutaneous and disappear with time.

Cover image of the 27th Conference Proceedings: A photo of two men herding cattle on horseback through a field of wildflowers in the Texas Hill Country. The men are wearing red western shirts and black cowboy hats. White background.

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Published

1995-09-14

Issue

1995

Section

Research Summaries 1