Penetration of Danofloxacin Into Tissues of the Respiratory and Gastrointestinal Tract in Calves

Authors

  • Christian Friis Department of Pharmacology and Pathobiology Royal Veterinary & Agricultural University 13 Bülowsvej, DK-1870 Frederiksberg, Denmark

DOI:

https://doi.org/10.21423/aabppro19926424

Keywords:

fluoroquinolone, pneumonia, enteritis, pharmacokinetics, respiratory tissue, gastrointestinal tract

Abstract

Danofloxacin* (CP-76,136) is a new fluoroquinolone which possesses high in vitro activity against the major bacterial pathogens in farm animals (1). The spectrum and potency of this drug indicate potential utility in the treatment of a broad range of infections, including pneumonia and enteritis. To guide effective therapy, this study focuses on the pharmacokinetics of danofloxacin in calves and the penetration of the drug into tissues of the respiratory and gastrointestinal tract.

Cover image of the First Volume of the 25th Conference Proceedings: An earl-morning photo of farmland. A small farm is nestled among rolling hills, fields stretching across a curving road that disappears between dark green trees. The barn is a cheery red color with a tin roof. Beneath the photo is the a statement of the conference's theme in white italics: Challenges of the Bovine Industry in the Twenty-First Century. Deep red background.

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Published

1992-08-31

Issue

1992: Volume 1

Section

Gastroenterology