La Fatigue Du Diaphragme

Un Risque Vital Au Cours Des Pneumonies?

Abstract

The effect of experimentally-induced pneumonia on diaphragmatic strength generation was studied in spontaneously breathing calves.

Five healthy male Friesian calves, 7 to 15 days old and weighing 44.5 ± 1.9 kg (mean± SE) were exposed to intratracheal instillation of 30 ml Pasteurella hemolityca Al broth (5.10 9 to 5.101° CFU/ml) in logarithmic phase of growth. The diaphragm was electrically stimulated via intracaval platinum electrodes mounted on a 12-gauge catheter introduced in the right jugular vein. The transdiaphragmatic pressure (Pdi) generated at functional residual capacity against occluded airways during supramaximal (60 V) 2-sec stimulations applied over a frequency range of 10-100 Hz was measured using conventional balloon catheters systems. The procedure was repeated before, 3, 6 and 9 hours after inoculation.

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