Use of Hydrogels to Vaccinate Calves Orally for Pneumonic Pasteurellosis

Authors

  • T. L. Bowersock School of Veterinary Medicine, Purdue University, West Lafayette, IN 17907
  • W. S. W. Shalaby School of Pharmacy, Purdue University, West Lafayette, IN
  • M. L. Samuels School of Math, Purdue University, West Lafayette, IN
  • M. R. White School of Veterinary Medicine, Purdue University, West Lafayette, IN
  • R. Lalone Southern Biotechnology Associates, Box 26221, Birmingham, AL, 35226
  • M. Levy School of Veterinary Medicine, Purdue University, West Lafayette, IN
  • D. Ryker School of Veterinary Medicine, Purdue University, West Lafayette, IN
  • K. Park School of Pharmacy, Purdue University, West Lafayette, IN

DOI:

https://doi.org/10.21423/aabppro19926444

Keywords:

hydrogels, antigens, mucosal sites, immunogenicity, oral vaccines

Abstract

This study showed that hydrogels can deliver antigens orally to ruminants resulting in immunity at distant mucosal sites. Studies are underway to determine what other antigens can be loaded into hydrogels and retain their immunogenicity when released into the lower GIT. Hydrogels provide a practical, safe, economical way to deliver oral vaccines to a large number of animals to prevent diseases which begin at a mucosal surface.

Cover image of the First Volume of the 25th Conference Proceedings: An earl-morning photo of farmland. A small farm is nestled among rolling hills, fields stretching across a curving road that disappears between dark green trees. The barn is a cheery red color with a tin roof. Beneath the photo is the a statement of the conference's theme in white italics: Challenges of the Bovine Industry in the Twenty-First Century. Deep red background.

Downloads

Published

1992-08-31

Issue

1992: Volume 1

Section

Respiratory Disease / Immunology