Penicillin Concentrations in Serum and Milk Following Administration of Procaine Penicillin G By Different Route at Different Dosage

Abstract

The aim of the clinician when using antimicrobials is to provide effective treatment while minimizing residues in milk and meat. Among all antibiotics used in food animals,
procaine penicillin G (PPG) is one of the oldest and is still one of the most widely used. Over the years, the recommended dosage has increased from 7, 500 IU /kg I. M. (the label dosage) to the recommended, but not approved dosage of 11,000 to 22,000 IU/kg administered I.M. or s.c. (1). The subcutaneous route is easier to use when large volumes need to be administered.

Because of the discrepancy between the approved dosage of PPG and the dosages currently used in clinical practice, the purposes of the present study were twofold: firstly to determine whether increasing doses of PPG would provide corresponding increases in efficacy, as measured by the peak serum concentration (Cmax) value and the length of time during which the serum concentration of PPG would exceed the minimum inhibitory concentration (MIC); secondly to determine whether the two routes of administration are comparable as true alternatives.

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