AT-4526, A New Quinolone Derivative

Its In Vitro and In Vivo Antibacterial Activity as a Veterinary Medicine

Authors

  • Yuzo Sakaguchi Bioscience Research Laboratories, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Kaoru Kouno Bioscience Research Laboratories, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Masahiro Nakai Ritto Experimental Farm, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Shuji Matsumoto Ritto Experimental Farm, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Hiromi Katae Ritto Experimental Farm, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Hiroaki Hattori Bioscience Research Laboratories, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Shinichi Nakamura Bioscience Research Laboratories, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan

DOI:

https://doi.org/10.21423/aabppro19926617

Keywords:

AT-4526, field isolates, antibacterial activities, in vitro, in vivo, bacterial infections, antibiotic resistance

Abstract

Various antibiotics have been used in the treatment of bacterial infections in domestic animals. In recent years, however, outbreaks of infections due to microorganisms resistant to antibiotics are often observed (1, 2, 3). The antibacterial quinolone derivatives does not show cross-resistance with antibiotics (4). AT-4526, 1-cyclopropyl-5,6,8-trifluoro-1 ,4- dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxoquinoline-3- carboxylic acid (Fig. 1), is a new quinolone derivative which was synthesized in 1986 (5). This compound, as well as the structurally related enrofloxacin (6), has a high order of activity against a broad spectrum of gram-positive, gram-negative bacteria, and Mycoplasma spp ..

This paper describes the in vitro and in vivo antibacterial activities of AT-4526 against field isolates in domestic animals and the comparison with those of enrofloxacin (ERFX), oxytetracycline (OTC), tylosin (TS), thiamphenicol (TP), kanamycin (KM) and ampicillin (ABPC).

Cover image of the Third Volume of the 25th Conference Proceedings: An earl-morning photo of farmland. A small farm is nestled among rolling hills, fields stretching across a curving road that disappears between dark green trees. The barn is a cheery red color with a tin roof. Beneath the photo is the a statement of the conference's theme in white italics: Challenges of the Bovine Industry in the Twenty-First Century. Deep red background.

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Published

1992-08-31

Issue

1992: Volume 3

Section

Respiratory Disease

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