Possible Effects of Dihydroheptaprenol on Neutrophil Function of Postpartum Dairy Cows

Authors

  • H. Nagahata Department of Animal Health, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan
  • G. J. Kociba Department of Veterinary Pathobiology, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, U.S.A.
  • H. Noda Department of Animal Health, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan
  • S. Araki Research and Development Division, Eisai Co., ltd., Koishikawa 5, Bunky6-ku, Tokyo 112, Japan
  • M. Kimura Research and Development Division, Eisai Co., ltd., Koishikawa 5, Bunky6-ku, Tokyo 112, Japan

DOI:

https://doi.org/10.21423/aabppro19926628

Keywords:

environmental mastitis, parturition, neutrophils, Dihydroheptaprenol, neutrophil function

Abstract

The parturient cow is highly susceptible to environmental mastitis. Severe clinical mastitis may occur shortly after parturition and is more severe than most cases of mastitis occurring in mid and late lactation periods (3). The enhanced susceptibility to mastitis may be attributable to the suppression of host defense mechanisms (3,4). The function of neutrophils is important for protection in the early phase of infection. However, little data are available on the function of neutrophils in dairy cows during the perinatal period (6, 7,10). Immunomodulators that might abrogate the development of periparturient immunosuppression have not been evaluated. Dihydroheptaprenol (DHP) is a polyprenol derivative and is known as a stimulator of neutrophils under experimental systems of mice (1,11) and swine (2). The present study was performed to determine whether DHP administration alters neutrophil function in dairy cows during the postpartum period.

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Published

1992-08-31

Issue

Section

Immunology