Sulfadimethoxine Withdrawal Time in Lactating Cows

Authors

  • George Weiss Roche Vitamins and Fine Chemicals, Nutley, N.J. 07110 U.S.A.
  • Alexander MacDonald Roche Vitamins and Fine Chemicals, Nutley, N.J. 07110 U.S.A.
  • Paul D. Duke Roche Vitamins and Fine Chemicals, Nutley, N.J. 07110 U.S.A.
  • Kabita Misra Roche Vitamins and Fine Chemicals, Nutley, N.J. 07110 U.S.A.
  • Michael R. Hannon Roche Vitamins and Fine Chemicals, Nutley, N.J. 07110 U.S.A.
  • Stan E. Katz Rutgers University, New Brunswick, N.J. 08903 U.S.A.
  • Marietta S. Brady Rutgers University, New Brunswick, N.J. 08903 U.S.A.
  • Glynn Horton Rutgers University, New Brunswick, N.J. 08903 U.S.A.

DOI:

https://doi.org/10.21423/aabppro19926656

Keywords:

drug residues, dairy industry, withdrawal, sulfadimethoxine, discard time

Abstract

Drug residues in milk have received much attention in recent months. Not surprisingly, the residue data collected by different groups, as well as the interpretation of its significance to public health, have been widely divergent The publicity generated has caused public concerns about the safety and wholesomeness of dairy products.

Because of these concerns and the recognized need of the dairy industry to strictly comply with the FDA requirements regarding allowable tolerance of approved drugs in milk, Hoffmann-La Roche and Rutgers University recently conducted a study to confirm the established milk discard (withdrawal) time following administration of sulfadimethoxine as Albon once-a-day Boluses to lactating dairy cows.

The original sulfadimethoxine tolerance of 10 ppb in milk, established after evaluation of extensive human food safety data by the Agency, remains in effect today. The recent study was conducted to determine if changes in dairy management and assay methods implemented since the original milk discard time was established, had changed the drug withdrawal time required to comply with the established tolerance.

Cover image of the Third Volume of the 25th Conference Proceedings: An earl-morning photo of farmland. A small farm is nestled among rolling hills, fields stretching across a curving road that disappears between dark green trees. The barn is a cheery red color with a tin roof. Beneath the photo is the a statement of the conference's theme in white italics: Challenges of the Bovine Industry in the Twenty-First Century. Deep red background.

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Published

1992-08-31

Issue

1992: Volume 3

Section

Mastitis