Failure of a novel surface polysaccharide targeting vaccine to prevent Tritrichomonas foetus infection in beef cattle
DOI:
https://doi.org/10.21423/aabppro20208112Keywords:
Tritrichomonas foetus, T. foetus, bovine trichomoniasis, immunization, pregnant cowsAbstract
Tritrichomonas foetus (T. foetus) is the causative agent of bovine trichomoniasis that has a major impact on production costs for beef cattle farmers. Immunization strategies to effectively protect against T. foetus are a high priority. T. foetus expresses a surface polysaccharide, beta 1-6 poly-Nacetyl glucosamine (PNAG). A PNAG-specific vaccine has demonstrated protection in pigs and horses. This study attempted to protect pregnant cows from an experimental T. foetus infection by prior vaccination with a PNAG-specific vaccine.