Characterization of the 13 cytopathic BVDV strains from mucosal disease cases from a single herd

Authors

  • M. F. Darweesh Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007
  • M. K. S. Rajput Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007
  • L. J. Braun Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007
  • J. D. Neill National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010
  • J. F. Ridpath National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010
  • C. C. L. Chase Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007

DOI:

https://doi.org/10.21423/aabppro20143698

Keywords:

Bovine viral diarrhea virus, BVDV, Noncytopathic, Cytopathic, mucosal disease

Abstract

Bovine viral diarrhea virus (BVDV) is a positive single-stranded RNA virus belonging to the Pestivirus genus of the Flaviviridae family. BVDV has a wide host range that includes most ruminants. Noncytopathic (ncp) BVDV may establish lifelong persistent infections in calves following infection of the fetus between 40 and 120 days of gestation. Cytopathic (cp) BVDV strains arise from ncp strains via mutations. The most common cp mutations are insertions of RNA derived from either host or a duplication of viral sequences into the region of the genome coding for the NS2/3 protein. Superinfection of a persistently infected animal with a cp virus can give rise to mucosal disease (MD), a condition that is invariably fatal.

Cover image of the 47th Conference Proceedings: An image of a herd of cattle in a field at dusk. Three cows are standing in the foreground, looking adorable. Yellow background.

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Published

2014-09-18

Issue

2014

Section

Research Summaries 1

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