Comparison of the Immune Response between a Pair of Noncytopathic and Cytopathic Bovine Viral Diarrhea Virus (BVDV) Type 1 Isolates

Authors

  • C. C. L. Chase Department of Veterinary Science, South Dakota State University, Brookings, SD
  • L. J. Braun Department of Veterinary Science, South Dakota State University, Brookings, SD
  • J. Ridpath National Animal Disease Center, Ames, IA
  • R. Harland Novartis Animal Health, Larchwood, IA

DOI:

https://doi.org/10.21423/aabppro20084469

Keywords:

Bovine viral diarrhea virus, BVDV, immune responses, vaccination, re-infection, noncytopathic, cytopathic

Abstract

Bovine viral diarrhea virus (BVDV) is a major pathogen of cattle causing severe respiratory and reproductive disease. BVDV vaccines remain an important part of the control strategy. Previous work has described higher antibody responses in animals infected with a noncytopathic (NCP) BVDV when compared to its cytopathic (CP) BVDV pair. Animals were re-infected 90 days later with either the same biotype or the other biotype. The animals infected with NCP initially were protected to a higher degree against re-infection with either biotype when compared to the animals infected with CP initially. In this study we wanted to see the effect of an initial infection (or vaccination) with a type 1 NCP or CP BVDV pair followed by infection with a virulent type 2 BVDV on clinical signs and immune responses.

Cover image of the 41st Conference Proceedings: A herd of cattle standing in the field, framed by a cloudy sky. Yellow background.

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Published

2008-09-25

Issue

2008

Section

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