Siderophore Receptor and Porin Protein Technology for Control of Salmonella and Escherichia coli 0157:H7 in Cattle

Abstract

Siderophore receptor and porin protein vaccine technology is a new tool to control clinical and subclinical bacterial disease in cattle through protection of exposed animals and decreased shedding in animals with enteric bacterial colonization. Data in this review have shown that the immune system of animals normally doesn't recognize SRP proteins. However, if primed the immune system will continue to increase the titer against these proteins without re-vaccination. These novel subunit Escherichia coli and salmonella vaccines have shown to decrease mortality and condemnation while increasing the performance in fed turkeys. The salmonella and E. coli 0157:H7 vaccines have shown to prevent mortality and decrease shedding of both salmonella and E. coli 0157:H7 in mice and cattle. The decrease in shedding and protection from subsequent disease leads to increased production, as illustrated by the results in dairy cow studies. After effectively demonstrating control of salmonella and E. coli, it is exciting to think of the potential that SRP vaccine technology has for control of numerous bacterial disease complexes in cattle such as bovine respiratory disease complex (BRDC), liver abscesses, footrot and pink eye.