Effect on in-vitro Cell Growth of Various Rehydrant Solutions

Abstract

In a controlled clinical study, the addition of Psyllium (a mucopolysaccharide derived from Isphagula seed shells) to a standard isotonic oral rehydrant solution (Deliver® with Dialine®, Pharmalett A/S, Denmark) reduced the duration, frequency and severity of diarrhea in newborn calves. This improvement of treatment is believed to be due to prolonged transit time through the small intestine, resulting in increased absorption of glucose and electrolytes. A new isotonic rehydrant solution (Deliver Extra, Pharmalett A/S, Denmark) was evaluated for its effect on in vitro cell growth. Deliver Extra is identical to Deliver® with Dialine® plus a mixture of important amino acids, including extra glutamine. Glutamine is included in Deliver Extra because it is a "limiting" amino acid that may play a role in diarrheal disease. It plays a role in maintaining mucosal integrity of the gut, and in controlled situations, glutamine has also been successful in enhancing the recovery of the damaged intestinal mucosa.