New Paradigms for Bovine Viral Diarrhea Virus

Understanding How BVDV Interacts with the Immune System

Authors

  • C. C. L. Chase Department of Veterinary Science, South Dakota State University, Brookings, SD 57007
  • G. Elmowalid Department of Veterinary Science, South Dakota State University, Brookings, SD 57007
  • L. J. Braun Department of Veterinary Science, South Dakota State University, Brookings, SD 57007
  • J. F. Ridpath Department of Veterinary Science, South Dakota State University, Brookings, SD 57007

DOI:

https://doi.org/10.21423/aabppro20035329

Keywords:

Bovine viral diarrhea virus, BVDV, persistent infection, fetus, macrophage function, surface marker expression

Abstract

Bovine viral diarrhea virus (BVDV) continues to be the bane of the US beef and dairy industry. BVDV infections cause clinical signs that vary from peracute death to inapparent infection. Even these inapparent BVDV infections can result in persistent infection (PI) of susceptible fetuses. The macrophage expresses cell surface markers that are important for phagocytosis and bacteria killing, and also for stimulation of T helper cells and for immune surveillance and killing by cytotoxic T cells (CTL). In this study, our objective was to measure the effect of BVDV on the macrophage function (phagocytosis and pathogen killing) and surface marker expression (CD14, MHCI and MHCII).

Cover image of the 36th Conference Proceedings: Holstein cows standing in a row at a fence. One cow has put her head through the fence and is curiously inspecting a pile of hay. Yellow background.

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Published

2003-09-18

Issue

2003

Section

Research Summaries - General