Bovisalm TM and Bovisalm D Vaccines are Safe and Prevent Salmonellosis in Calves

Authors

  • J. M. de Ree Solvay Duphar B.V. , Animal Health Division, P.O. Box 900 1380 DA Weesp, The Netherlands
  • B. G. E. Stuurman Solvay Duphar B.V. , Animal Health Division, P.O. Box 900 1380 DA Weesp, The Netherlands
  • A. M. Mollema Solvay Duphar B.V. , Animal Health Division, P.O. Box 900 1380 DA Weesp, The Netherlands
  • J. W. Zantinga Solvay Duphar B.V. , Animal Health Division, P.O. Box 900 1380 DA Weesp, The Netherlands
  • P. van der Valk Solvay Duphar B.V. , Animal Health Division, P.O. Box 900 1380 DA Weesp, The Netherlands

DOI:

https://doi.org/10.21423/aabppro19926419

Keywords:

Bovine salmonellosis, vaccines, mucosal immunity, lyophilized vaccines, veal calves

Abstract

Bovine salmonellosis is an important zoonotic infection1. Serious outbreaks of clinical disease may occur in cattle of all ages and result in devastating economic loss. The most important serotypes which cause disease in calves are Salmonella typhimurium and Salmonella dublin. Both serotypes can cause fever, anorexia, depression, bacteremia, diarrhoea and death.

Live and dead vaccines have been used to prevent salmonellosis in calves. It is generally believed that cell mediated immunity is necessary to provide longterm protection against salmonellosis. For this reason live attenuated strains have been used because these strains elicit a stronger cell mediated immunity than killed vaccines. Furthermore orally delivered vaccines cause a mucosal immunity, which is important for protection against enteric pathogens.

A number of different types of live vaccines have been developed. Auxotrophic mutants are dependent on metabolites not, or insufficiently present in the vaccinated animal. Recently, a Salmonella typhimurium strain was described which is auxotrophic for histidine and adenine and which also shows a high sensitivity to tensides2. Furthermore Salmonella dublin strain was described which is auxotrophic for thiamine and adenine. These strains have been used for the development of Bovisalm TM (S. typhimurium) and Bovisalm D (S. dublin); lyophilized vaccines for oral immunization of young veal calves to prevent salmonellosis. In this report we present data to show that these strains are safe and effective in preventing salmonellosis in calves.

Cover image of the First Volume of the 25th Conference Proceedings: An earl-morning photo of farmland. A small farm is nestled among rolling hills, fields stretching across a curving road that disappears between dark green trees. The barn is a cheery red color with a tin roof. Beneath the photo is the a statement of the conference's theme in white italics: Challenges of the Bovine Industry in the Twenty-First Century. Deep red background.

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Published

1992-08-31

Issue

1992: Volume 1

Section

Gastroenterology