AT-4526, A New Quinolone Derivative

Its Pharmacokinetics in Cats, Dogs, Pigs, and Calves

Authors

  • Kaoru Kouno Bioscience Research Laboratories, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Yuzo Sakaguchi Bioscience Research Laboratories, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Masahiro Nakai Ritto Experimental Farm, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Motonobu Yoshida Ritto Experimental Farm, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Shuji Matsumoto Ritto Experimental Farm, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Tadashi Kawamura Ritto Experimental Farm, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Naonobu Hatano Ritto Experimental Farm, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Hiromi Katae Ritto Experimental Farm, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Hiroaki Hattori Bioscience Research Laboratories, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan
  • Shinichi Nakamura Bioscience Research Laboratories, Dainippon Pharmaceutical Co., Ltd. Enoki 33-94, Suita, Osaka 564, Japan

DOI:

https://doi.org/10.21423/aabppro19926615

Keywords:

quinolone derivative, antibacterial, Mycoplasma spp, gram-positive, gram-negative, pharmacokinetics, AT-4526, cats, dogs, pigs, calves

Abstract

AT-4526, 1-cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid, a new quinolone derivative, is under development as veterinary medicine. It has broad and potent antibacterial activities against gram-positive and gram-negative bacteria, anaerobes and Mycoplasma spp. (1). Its in vivo activity was generally higher than those of structurally related enrofloxacin and certain antibiotics such as oxytetracycline, kanamycin, and ampicillin in experimental infections in mice even in the case of less potent in vitro activity (1).

This paper describes the pharmacokinetics of AT-4526 in cats, dogs, pigs and calves.

Cover image of the Third Volume of the 25th Conference Proceedings: An earl-morning photo of farmland. A small farm is nestled among rolling hills, fields stretching across a curving road that disappears between dark green trees. The barn is a cheery red color with a tin roof. Beneath the photo is the a statement of the conference's theme in white italics: Challenges of the Bovine Industry in the Twenty-First Century. Deep red background.

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Published

1992-08-31

Issue

1992: Volume 3

Section

Respiratory Disease

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