AT-4526, A New Quinolone Derivative

Its Clinical Evaluation on Bacterial Respiratory Disease and Diarrhea in Calves

Authors

  • Katsumoto Kagota Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Etsuji Hakogi Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Susumu Noma Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Yoshiyuki Maruo Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Norio Emoto Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Toyoyuki Maeda Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Masahisa Kishimoto Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Yasuo Yoneda Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Shyogen Ryo Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Masaaki Koiwa Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Tatehiko Abe Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Hiroyuki Yamanaka Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Akira Anri Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Yasuyuki Yoshida Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Takashi Umemura Tottori University and Veterinary Clinical Study Groups of AT-4526, Koyama-cha Minami 4-101, Tottori, Tottori 680, Japan
  • Yasuaki Shimada University of Osaka Prefecture and Veterinary Clinical Study Groups of AT-4526

DOI:

https://doi.org/10.21423/aabppro19926616

Keywords:

antibacterial agents, antibiotics, Bacterial respiratory diseases, quinolone derivative, diarrhea, AT-4526

Abstract

Bacterial respiratory diseases and diarrhea in the calves are causing great economic losses. So, antibacterial agents are often used to prevent and medicate to the diseases. Recently, bacteria resistant to antibiotics are increasing and causing severe problem in clinical field (1, 2). AT-4526, 1-cyclopropyl-5,6,8-trifluoro-l, 4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid, a new quinolone derivative, has broad and potent antibacterial activity, and is not cross-resistanct with antibiotics (3). It is well absorbed and distributed to most tissues of calves by intramuscular (i.m.) administration (4). Therefore, it is suggested that AT-4526 is useful for bacterial diseases in various animals. This report describes the efficacies of AT-4526 against spontaneous bacterial respiratory diseases and diarrhea in calves.

Cover image of the Third Volume of the 25th Conference Proceedings: An earl-morning photo of farmland. A small farm is nestled among rolling hills, fields stretching across a curving road that disappears between dark green trees. The barn is a cheery red color with a tin roof. Beneath the photo is the a statement of the conference's theme in white italics: Challenges of the Bovine Industry in the Twenty-First Century. Deep red background.

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Published

1992-08-31

Issue

1992: Volume 3

Section

Respiratory Disease