Infectious Bovine Keratoconjunctivitis
Comparison of Immunological Response and Disease Reproduction in Vaccinated and Non-Vaccinated Calves
DOI:
https://doi.org/10.21423/aabppro19837407Keywords:
Infectious Bovine Keratoconjunctivitis, immunological response, disease reproduction, vaccinated calves, non-vaccinated calves, M. bovis vaccineAbstract
Moraxella bovis is considered to be the main causative agent of infectious bovine keratoconjunctivitis (IBK), commonly known as pinkeye1 2. IBK has been reproduced with M. bovis organisms alone3 or in combination with other enhancing factors4 8. Numerous attempts have been made to produce a M. bovis vaccine utilizing viable and nonviable organisms in both experimental and natural environmental conditions9 13. Preliminary studies have indicated several cross antigens between our Neisseria vaccine and M. bovis. This apparent
cross antigenicity appears to be the basis for the induced protective immunity to M. bovis. A vaccine utilizing the concept of cross-antigenicity is currently used in inducing resistance against canine distemper with a modified live measles virus. a.Why M. bovis does not produce a similar immunity to itself is unclear. This may be the key to both the pathogenicity of M. bovis in bovine cornea and the difficulty
of previous investigators in using M. bovis as an effective vaccine against itself.
