Acute puerperal metritis

Antimicrobial therapy and the relationship between antimicrobial pharmacodynamics and therapeutic success

Authors

  • Brent C. Credille Food Animal Health and Management Program, College of Veterinary Medicine, University of Georgia, Athens, GA 30602
  • Steeve Giguere Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602

DOI:

https://doi.org/10.21423/bovine-vol49no1p18-24

Keywords:

dairy cow, metritis, antimicrobial, therapy, ampicillin, antiinfective agents, bacterial diseases, ceftiofur, cows, culling, dairy cattle, dairy cows, endometritis, losses, milk production, milk yield, oxytetracycline, pharmacodynamics, pharmacokinetics, postpartum period, reproductive performance, risk, uterus, beta-lactam antibiotics, antibiotics, tetracyclines

Abstract

Acute puerperal metritis is a common disease in postpartum dairy cattle. This disease causes significant economic losses as affected cows experience reduced milk production, increased culling risk, and impaired reproductive performance. Acute puerperal metritis is invariably associated with bacterial colonization and infection of the uterus. As a result, antimicrobials are a mainstay of therapy for this disease. Optimal dosing of antimicrobial agents is essential to therapeutic success, and designing dosing regimens requires an integration of both pharmacokinetic and pharmacodynamic principles. The goals of this article are to provide an overview of the current state of knowledge of antimicrobial treatment options in cattle with acute puerperal metritis, and review the principles of antimicrobial pharmacodynamics.
Cover image of Volume 49, No. 1 of the Bovine Practitioner: A photo of an old two-story wooden farmhouse with a rusted tractor in the front yard. A single cow is grazing near an outbuilding.

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Published

2015-02-01

How to Cite

Credille, B. C., & Giguere, S. (2015). Acute puerperal metritis: Antimicrobial therapy and the relationship between antimicrobial pharmacodynamics and therapeutic success. The Bovine Practitioner, 49(1), 18–24. https://doi.org/10.21423/bovine-vol49no1p18-24

Issue

Vol. 49, No. 1 (2015 Spring)

Section

Articles