Evaluation of a novel vaccine based on siderophore receptor proteins and porins (SRP Technology) for controlling Klebsiella mastitis in a dairy herd

Abstract

Siderophore receptor proteins (SRP) are iron-regulated proteins shown to be highly conserved between members of the family Enterobacteriaceae, making them novel vaccine targets. Siderophore receptor proteins of Salmonella Newport have been successfully exploited to control Salmonella Newport in the dairy industry for over a decade. This same technology has now been developed to combat Klebsiella mastitis. The objective of this study was to evaluate efficacy of a Klebsiella vaccine based on SRP technology to reduce Klebsiella mastitis in a dairy herd with ongoing disease that was not controlled with JS vaccination. The study was conducted at the Iowa State University (ISU) Dairy in Ames, Iowa.