Evaluation of a Novel Vaccine Consisting of Siderophore Receptor Proteins and Porins for Controlling Salmonellosis in a Commercial Dairy Herd

Authors

  • Daryll Emery Willmar Poultry Company, Willmar, Minnesota 56201
  • Darren Straub Willmar Poultry Company, Willmar, Minnesota 56201
  • Larry Slinden Willmar Poultry Company, Willmar, Minnesota 56201

DOI:

https://doi.org/10.21423/aabppro20015200

Keywords:

subunit vaccine, siderophore receptor proteins, Salmonella, milk production

Abstract

The purpose of this study was to determine the safety of an autogenous subunit vaccine consisting of a highly purified preparation of siderophore receptor proteins and porins (SRP-P) derived from Salmonella bredeney. The organism was isolated from a commercial dairy herd showing severe clinical signs of salmonellosis: acute enteritis and septicemia resulting in high adult and calf mortality and morbidity. The vaccine was given to all cows (n=125) in the herd. The experimental trial examined the safety of the immunizing composition based on tissue reactivity of the injected material at the site of injection; loss of milk production after vaccination; serological response to vaccination; and effect on the incidence of salmonella within the herd.

Cover image of the 34th Conference Proceedings: Four men on horseback lead a single cow through a pen. Yellow background.

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Published

2001-09-13

Issue

2001

Section

Research Summaries - Dairy