Evaluation of a Novel Vaccine Consisting of Siderophore Receptor Proteins and Porins for Controlling Salmonellosis in a Commercial Dairy Herd
DOI:
https://doi.org/10.21423/aabppro20015200Keywords:
subunit vaccine, siderophore receptor proteins, Salmonella, milk productionAbstract
The purpose of this study was to determine the safety of an autogenous subunit vaccine consisting of a highly purified preparation of siderophore receptor proteins and porins (SRP-P) derived from Salmonella bredeney. The organism was isolated from a commercial dairy herd showing severe clinical signs of salmonellosis: acute enteritis and septicemia resulting in high adult and calf mortality and morbidity. The vaccine was given to all cows (n=125) in the herd. The experimental trial examined the safety of the immunizing composition based on tissue reactivity of the injected material at the site of injection; loss of milk production after vaccination; serological response to vaccination; and effect on the incidence of salmonella within the herd.