Experimental infection of pregnant sheep with bovine viral diarrhea virus 1b (AU526)

Authors

  • T. Kuca Departments of Clinical Sciences and Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849
  • T. Passler Departments of Clinical Sciences and Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849
  • K. P. Riddell Departments of Clinical Sciences and Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849
  • J. D. Neill Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, Department of Agriculture, ARS, Ames, IA 50010
  • B. W. Newcomer Departments of Clinical Sciences and Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849
  • P. H. Walz Departments of Clinical Sciences and Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849

DOI:

https://doi.org/10.21423/aabppro20153613

Keywords:

Bovine viral diarrhea virus, BVDV, host specificity, serial infection, pregnancy

Abstract

Bovine viral diarrhea virus (BVDV) lacks strict host specificity and can infect many species in the order Artiodactyla. BVDV infection in pregnant heterologous hosts can be deleterious. Limited information exists regarding genomic changes occurring in BVDV upon infection of heterologous hosts. Using a BVDV isolate previously demonstrated to cause PI cattle, goats, and white-tailed deer, this study investigated the outcome of serial infection in pregnant BVDV-naive sheep, a heterologous species that is phylogenetically closely related to cattle.

Cover image of the 48th Conference Proceedings: An image of Dr. Fred Gingrich II dressed in a red shirt and overalls and standing in front of dairy cows in a barn interior. Yellow background.

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Published

2015-09-17

Issue

2015

Section

AASRP Research Summaries

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