Efficacite D'Une Nouvelle Cephalosporine (Ceftiofur) Associee Ou Non A Un Antiinflammatoire Steroidien (Succinate De Methyl Prednisolone) Dans Un Modele Experimental De Pasteurellose Respiratoire Du Veau A Pasteurella Haemolytica Bio-Serogroupe Al

Authors

  • J. Espinasse Département de Physiopathologie Animale, Ecole Nationale Vétérinaire, 23 chemin des Capelles, 31076 Toulouse Cedex
  • F. Bost Laboratoire Upjohn, Tour Franklin, 92042 Paris La Défense Cedex 11
  • A. Madelenat Département de Physiopathologie Animale, Ecole Nationale Vétérinaire, 23 chemin des Capelles, 31076 Toulouse Cedex
  • F. Schelcher Département de Physiopathologie Animale, Ecole Nationale Vétérinaire, 23 chemin des Capelles, 31076 Toulouse Cedex
  • J. -F. Valarcher Département de Physiopathologie Animale, Ecole Nationale Vétérinaire, 23 chemin des Capelles, 31076 Toulouse Cedex

DOI:

https://doi.org/10.21423/aabppro19926435

Keywords:

antibiotic, steroidal anti-inflammatory treatment, Pha1 isolate, Ceftiofur, mean disease score

Abstract

After randomization, 18 calves were inoculated with a Pha1 isolate as described in an earlier protocol. After the first inoculation 6 calves received Ceftiofur (CEF), 1 mg/kg by intramuscular route (IM) every day for 5 days together with methyl-prednisolone-succinate (MPS) 3 mg/kg IM on two consecutive days, 6 calves received CEF + an MPS placebo, and 6 calves a CEF placebo+ an MPS placebo. Twice a day before the meal all calves were clinically examined to determine a mean disease score (MOS). After their death or sacrifice, 7 days at most after the first inoculation, all calves were autopsied. The lungs were weighed, the extent of the lesions quantified by a score (mean lung score= MLS) based on combined inspection and palpation and a quantitative bacteriological examination carried out on the damaged lung parenchyma. The validity of the model was confirmed by the percentage mortality observed in the control group (83 % versus 17 % in the other groups). A similar trend was apparent in the clinical results (significant difference p ≤ 0,05 between the mean MOS of the control group and that of the other group) in the necropsy results (significant difference p ≤ 0,05 between the control group and the other groups for mean lung weight and MLS)) and in the microbiological results (significant difference p ≤ 0,05 between the mean number of cfu Pha1/g of lung in the control group and other groups). This demonstrate the efficacy of both therapeutic regimens (i.e. CEF and CEF + MPS) in our model. The advantage of the antibiotic + steroidal anti-inflammatory treatment is not clear.

Full article in French, English and German summary in PDF.

Downloads

Published

1992-08-31

Issue

Section

Respiratory Disease