Comparative Minimum Inhibitory Concentrations of Danofloxacin and Six Commonly Used Antibacterials Against Pasteurella and Haempophilus From Pneumonic Cattle

Authors

  • Dirk L. Raemdonck Pfizer Animal Health Group, NY 10017, USA
  • A. C. Tanner Central Research Division, Pfizer Inc, Terre Haute, IN 47808, USA
  • S. T. Tolling Pfizer Animal Health Group, NY 10017, USA
  • S. L. Michener Pfizer Animal Health Group, NY 10017, USA

DOI:

https://doi.org/10.21423/aabppro19926621

Keywords:

Fluoroquinolone antimicrobials, DNA gyrase, bacterial enzyme, respiratory pathogens

Abstract

Fluoroquinolone antimicrobials exhibit inhibitory and bactericidal activity by blocking DNA gyrase (topoisomerase II), an essential bacterial enzyme.1 These compounds possess excellent antimicrobial activity against bacterial and mycoplasmal pathogens, however few in-vitro studies have been conducted to evaluate the activity of fluoroquinolone antimicrobials against respiratory pathogens of veterinary significance2,3,4 This report summarizes the results of an extensive survey to determine Minimum Inhibitory Concentrations (MIC) of danofloxacin*, a new fluoroquinolone antimicrobial, and six commonly used antibacterials against P. haemolytica, P. multocida, and H.somnus isolated from pneumonic cattle.

Cover image of the Third Volume of the 25th Conference Proceedings: An earl-morning photo of farmland. A small farm is nestled among rolling hills, fields stretching across a curving road that disappears between dark green trees. The barn is a cheery red color with a tin roof. Beneath the photo is the a statement of the conference's theme in white italics: Challenges of the Bovine Industry in the Twenty-First Century. Deep red background.

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Published

1992-08-31

Issue

1992: Volume 3

Section

Respiratory Disease