The 15-membered ring macrolide tulathromycin inhibits plasma endotoxin activity in endotoxemic calves

Authors

  • M. Otsuka The School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501 Japan
  • Y. Nishi The School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501 Japan
  • K. Tsukano The School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501 Japan
  • T. Fukuda The School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501 Japan
  • M. Tsuchiya Microbial Solutions, Charles River, Charleston, SC 29407
  • K. Suzuki The School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501 Japan

DOI:

https://doi.org/10.21423/aabppro20183206

Keywords:

antibiotics, Macrolide antibiotics, bacteriostatic, cytokine, inflammatory pneumonia, endotoxin, tulathromycin-containing plasma inhibited endotoxin, ETX

Abstract

Macrolide antibiotics have not only bacteriostatic effects, but also anti-inflammatory effects via the inhibition of cytokine release. The 15-membered ring macrolide tulathromycin is widely used for cattle with inflammatory pneumonia. However, its anti-inflammatory activity, especially against endotoxin, remains unclear. The purpose of this study was to investigate whether tulathromycin-containing plasma inhibited endotoxin (ETX) activity in vivo and in vitro.

Cover image of the 51st Conference Proceedings: A man riding on a pale horse herding cattle on a semi-arid pasture

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Published

2018-09-13

Issue

2018

Section

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