Profiles of serum amino acids to screen for catabolic and inflammation status in calves with mycoplasma bronchopneumonia

Abstract

Amino acid metabolism in cancer cells is significantly altered compared with that of normal cells. These changes are also reflected in the plasma amino acid profiles of patients with various types of inflammatory disease in human. Our hypothesis is that serum amino acid profiles of calves with mycoplasma Effecbronchopneumonia will be similar to those in human disease due to the inflammation and generalized catabolic state of these animals. The aim of this study was to investigate the relationships with serum amino acid profiles, total amino acids (TAA), branched amino acid:aromatic amino acid (BCAA/AAA) ratio, branched chain amino acid to tyrosine ratio (BTR) and serine to phosphorserine ratio (SPR) in calves with lung inflammation associated with mycoplasma bronchopneumonia. Receiver operative characteristic (ROC) curves was constructed to describe the performance of amino acid profiles in calves with mycoplasma bronchopneumonia. These data may be useful diagnostically and prognostically in calves with bronchopneumonia.