Further obervations on the use of Iα-Hydroxycholecalciferol in the prevention of bovine partutrient paresis

Abstract

Varying doses of lahydroxycholecalciferol (lα-HCC) (50, 150, 250 and 350 micrograms) in propylene glycol were injected intramuscularly into 30 dry adult Israeli Friesian cows. Four of these animals received a second dose (250 or 350 Hg) 48 hours later or ten (350 Hg) 72 hours after the first dose.

The effective use of this derivative in practice depends, therefore, on the accurate prediction of calving. Furthermore, the minimal effective dose has not been determined. In the present study, dose response curves to lαHCC were obtained, and parturition induction by flumethasone has been tried in an effort to overcome the difficult problem of timing.