Comparative evaluation of therapeutic trials in experimentally induced lead toxicosis in crossbred calves

Authors

  • S. S. Randhawa Department of Veterinary Medicine, Punjab Agricultural University, Ludhiana 14100, Punjab, India
  • Gurdeep Singh Department of Veterinary Medicine, Punjab Agricultural University, Ludhiana 14100, Punjab, India
  • D. C. Nauriyal Department of Veterinary Medicine, Punjab Agricultural University, Ludhiana 14100, Punjab, India
  • R. S. Brar Department of Veterinary Pathology, Punjab Agricultural University, Ludhiana 14100, Punjab, India

DOI:

https://doi.org/10.21423/bovine-vol1995no29p136-139

Keywords:

animal experiments, anticoagulants, blood, calves, chelating agents, chemistry, creatinine, edta, enzymes, lead, lead poisoning, oxidoreductases, poisoning, symptoms, transferases, treatment

Abstract

Lead toxicosis was induced by oral administration of lead acetate (10 mg/kg body weight) in 10 crossbred, 6-9-month-old calves. Blood biochemical analysis revealed anaemia, significant increase in mean plasma activity of AST, ALP, LDH and GGT enzymes associated with significant increase in BUN and plasma creatinine contents by 40th day of induction. Parenteral treatment with Na2EDTA-calcium borogluconate combination along with thiamine hydrochloride was more effective than treatment comprising Na2EDTA-calcium borogluconate combination alone in restoring blood biochemical and plasma enzymatic values with early and full clinical recovery.

Cover image of the 29th Volume of the Bovine Practitioner: a photo of the San Antonio Riverwalk as seen from a riverside restaurant. Tables of patrons converse and watch a docking riverboat filled with passengers.

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Published

1995-09-01

Issue

No. 29 (1995 September)

Section

Articles

How to Cite

Comparative evaluation of therapeutic trials in experimentally induced lead toxicosis in crossbred calves. (1995). The Bovine Practitioner, 1995(29), 136-139. https://doi.org/10.21423/bovine-vol1995no29p136-139