Serological response to administration of Brucella abortus strain RB51 vaccine in beef and dairy heifers, using needle-free and standard needle-based injection systems

Authors

  • Alda F. A. Pires William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA 95616
  • Bruce R. Hoar Department of Medicine and Epidemiology, University of California, Davis, CA 95616
  • William M. Sischo Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616
  • Steven C. Olsen Bacterial Diseases of Livestock Research Unit (Olsen) National Animal Disease Center, USDA I ARS, IA 50010

DOI:

https://doi.org/10.21423/bovine-vol45no2p102-107

Keywords:

bovine, vaccination, brucella, needle-free injection, antibodies, bacterial diseases, beef cattle, brucellosis, cell mediated immunity, dairy cattle, drug delivery systems, efficacy, heifers, humoral immunity, immune response, immunity, injection, methodology, potency, strains, vaccines

Abstract

More than four million doses of Brucella abortus strain RB51 (SRB51) are administered in the United States every year. Accidental autoinoculation of humans has the potential to result in local and systemic symptoms; therefore, investigation of alternative delivery methods is warranted. The objective of this study was to compare the immunologic responses of four to eight-month-old beef and dairy heifers to vaccination with 1010 colony-forming units of SRB51, delivered either by standard needle-and-syringe system or needle-free injection system. There was no difference in the 30-day SRB51 antibody response to the two vaccination methods, and no difference in response between beef and dairy heifers. These data demonstrate that the humoral immune response of heifers to vaccination with SRB51 using a needle-free injection system is similar to the response obtained with a standard needle system. Further studies to define the cellular immune response and protection against infection are recommended before this administration method is considered for routine use.

Cover image of Volume 45, No.2 of the Bovine Practitioner: a photo of a group of cattle examining a Jeep in a field. The Jeep has the licence plate "BEEF."

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Published

2011-06-01

How to Cite

Pires, A. F. A., Hoar, B. R., Sischo, W. M., & Olsen, S. C. (2011). Serological response to administration of Brucella abortus strain RB51 vaccine in beef and dairy heifers, using needle-free and standard needle-based injection systems. The Bovine Practitioner, 45(2), 102–107. https://doi.org/10.21423/bovine-vol45no2p102-107

Issue

Vol. 45, No. 2 (2011 Summer)

Section

Articles

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