Vaccine associated mucosal disease case study

Demonstrating the importance of subsequent herd PI testing

Authors

  • Myrna M. Miller Wyoming State Veterinary Laboratory, Department of Veterinary Sciences, College of Agriculture and Natural Sciences, University of Wyoming, Laramie, WY 82070
  • Donal O'Toole Wyoming State Veterinary Laboratory, Department of Veterinary Sciences, College of Agriculture and Natural Sciences, University of Wyoming, Laramie, WY 82070
  • Jacqueline L. Cavender Wyoming State Veterinary Laboratory, Department of Veterinary Sciences, College of Agriculture and Natural Sciences, University of Wyoming, Laramie, WY 82070
  • Todd E. Cornish Wyoming State Veterinary Laboratory, Department of Veterinary Sciences, College of Agriculture and Natural Sciences, University of Wyoming, Laramie, WY 82070
  • Timothy G. Dawson Bi-State Large Animal Hospital, 10321 Polo Ranch Road, Cheyenne, WY 82003
  • J. Maxwell Smylie Smylie Animal Clinic, 93 West Richards Street, Douglas, WY 82633
  • Jonathan H. Fox Wyoming State Veterinary Laboratory, Department of Veterinary Sciences, College of Agriculture and Natural Sciences, University of Wyoming, Laramie, WY 82070
  • Kevin L. Hill US Cattle Technical Services, Merck Animal Health, 447 N. Angel Street, Kaysville, UT 84037
  • Donald L. Montgomery Wyoming State Veterinary Laboratory, Department of Veterinary Sciences, College of Agriculture and Natural Sciences, University of Wyoming, Laramie, WY 82070
  • Marce Vazquez Wyoming State Veterinary Laboratory, Department of Veterinary Sciences, College of Agriculture and Natural Sciences, University of Wyoming, Laramie, WY 82070
  • Brant A. Schumaker Wyoming State Veterinary Laboratory, Department of Veterinary Sciences, College of Agriculture and Natural Sciences, University of Wyoming, Laramie, WY 82070

DOI:

https://doi.org/10.21423/bovine-vol47no2p84-93

Keywords:

bovine viral diarrhea, BVD, mucosal disease, PI, cattle, vaccine, carcasses, immune response, laboratories, mucosa, steers, strains, vaccination, vaccines

Abstract

Mucosal disease (MD) affected a single-source group of 461 recently purchased yearling steers shortly after vaccination with a multivalent vaccine containing 2 strains of modified-live bovine viral diarrhea virus (BVDV). Terminal disease affected 21 steers at 18 to 66 days post-vaccination, and was confirmed as mucosal disease in 3 carcasses examined postmortem. An additional 17 animals identified as persistently infected remained asymptomatic during the study A laboratory study was undertaken to determine whether mucosal disease was triggered by a BVDV in the multivalent vaccine. Purified cytopathic BVDV isolates from 2 animals that died early in the outbreak were genetically identical (>99%) to the vaccine type 2 BVDV strain 125a in 3 genomic regions: 5â²-untranslated region to the Npro, E2, and NS2/3. This genetic identity combined with the presence of a single peak outbreak occurring soon after vaccination suggests that the vaccine BVDV was the cause of mucosal disease in these steers. The investigation underscores laboratory challenges in determining the role of vaccinal BVDV when mucosal disease affects multiple animals within 2 months of vaccination, and the need for laboratory testing to identify all persistently infected animals.

Cover image of Volume 47, No.2 of the Bovine Practitioner: a photo of a Red and White Holstein centered in the frame, bending down slightly to sniff at the photographer. In the background you can see a few other cows and the edge of a forest.

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Published

2013-06-01

Issue

Vol. 47, No. 2 (2013 Summer)

Section

Articles

How to Cite

Vaccine associated mucosal disease case study: Demonstrating the importance of subsequent herd PI testing. (2013). The Bovine Practitioner, 47(2), 84-93. https://doi.org/10.21423/bovine-vol47no2p84-93

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