Systemic and local immune responses of weaned beef calves vaccinated post-transportation and at the time of a mild respiratory tract infection

Authors

  • Victor S. Cortese Zoetis, Inc., 8601 Glenfield Way, Louisville, KY 40241
  • Amelia R. Woolums Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, MS 39762
  • Brandi B. Karisch Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS 39762
  • Thomas H. Short Zoetis, Inc., Parsippany, NJ 07054
  • Merrilee Thoresen Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, MS 39762
  • Peres Badial Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, MS 39762

DOI:

https://doi.org/10.21423/bovine-vol54no1p58-65

Keywords:

bovine, mucosal immunity, vaccination, stress, shipping

Abstract

To examine the effects of transport stress and concur-rent respiratory infection on bovine vaccine responses, 75 previously weaned beef calves were randomly assigned to 1 of 3 treatments (n=25/group). Group 1 calves were not transported, but were vaccinated (NTV). Both Groups 2 (vaccinated TV) and 3 (not vaccinated TUV) were transported for 12 h. Twelve h after transport, calves in NTV and TV groups were vaccinated intranasally with modified-live bovine respiratory syncytial virus (BRSV), bovine herpesvirus −1 (BHV-1), and parainfluenza virus type 3 (PI3V), and subcutaneously with modified-live bovine viral diarrhea virus (BVDV) types 1 and 2 vaccine with Mannheimia hemolytica (Mh) leukotoxoid vaccine. Nasal secretions and serum were collected pre- and post-vaccination for measurement of nasal interferon alpha, beta, and gamma, IgA to BHV-1 and BRSV, and serum neutralizing (SN) titers to BHV-1, BRSV, and BVDV types 1 and 2.

At vaccination some calves had nasal discharge and fever. Pre-vaccination nasal swabs, tested for respiratory viruses, were negative. During the 21-d study, 6 calves developed BRD and eventually recovered. BHV-1 and BVDV 1 and 2 SN titers were significantly higher in vaccinated than nonvaccinated calves on d 14 and 21. BVDV2 titers were significantly higher in TV than NTV. Vaccination stimulated systemic, but not mucosal, antibody responses. Cattle can mount a humoral response to vaccination in spite of transport and mild respiratory disease.

Cover image of Volume 54, No. 1 of the Bovine Practitioner: a photo of an Angus cow with her calf by her side, both gazing at the photographer. The calf is very small, only a little taller than the grass both cows are standing in.

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Published

2020-02-01

How to Cite

Cortese, V. S., Woolums, A. R., Karisch, B. B., Short, T. H., Thoresen, M., & Badial, P. (2020). Systemic and local immune responses of weaned beef calves vaccinated post-transportation and at the time of a mild respiratory tract infection. The Bovine Practitioner, 54(1), 58–65. https://doi.org/10.21423/bovine-vol54no1p58-65

Issue

Vol. 54, No. 1 (2020 Spring)

Section

Articles

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