A comparison of two multivalent modified live viral/bacterial combination vaccines in feedlot calves at ultra-high risk of developing undifferentiated fever/bovine respiratory disease

Authors

  • Breck D. Hunsaker TELUS Agriculture, Okotoks, AB T1S 2A2
  • Christopher A. McMullen TELUS Agriculture, Okotoks, AB T1S 2A2
  • Courtney G. Stamm TELUS Agriculture, Okotoks, AB T1S 2A2
  • Tye Perrett TELUS Agriculture, Okotoks, AB T1S 2A2
  • Sherry J. Hannon TELUS Agriculture, Okotoks, AB T1S 2A2
  • Lonty K. Bryant Merck Animal Health, Madison, NJ 07940
  • Calvin W. Booker TELUS Agriculture, Okotoks, AB T1S 2A2

DOI:

https://doi.org/10.21423/bovine-vol58no2p23-33

Keywords:

shipping fever, beef, immunization

Abstract

Vaccine 1 (VAC1 group) and Vaccine 2 (VAC2 group) are com­mercially available vaccines labeled for the control of bovine respiratory disease (BRD) in beef cattle. There are limited data from large-scale commercial feedlot trials comparing VAC1 and VAC2 arrival processing vaccination pro­grams. The objective of this study was to evaluate the relative effects of VAC1 and VAC2 arrival processing vacci­nation programs on animal health, feedlot performance and carcass characteristic outcomes in feedlot calves at ultra-high risk of developing undifferentiated fever/BRD under large-scale commercial production conditions. Animals were randomly allocated at feedlot arrival to 1 of 2 experimental groups: VAC1 or VAC2.  Animals in the VAC1 group (6 multi-pen lots; 3,001 animals) received a bovine rhinotracheitis-virus diarrhea-parainfluenza 3-respiratory syncytial virus-Mannheimia hae­molytica-Pasteurella multocida vaccine per animal once at allocation. Animals in the VAC2 group (6 multi-pen lots; 3,005 animals) received a bovine rhinotracheitis-virus diarrhea-parainfluenza 3-respiratory syncytial virus vaccine with a Mannheimia haemolytica toxoid per animal once at allocation. Vaccines differed regarding viral strains, bacterial protection, means for providing bacterial immunity, and adjuvant use. Animals were housed by experi­mental group in commercial feedlot pens and followed from allocation until slaughter. Although histophilosis mortality was higher in the VAC1 group compared to the VAC2 group (P = 0.040), no statistical differences were detected in overall mor­tality or any of the other outcome variables (P ≥ 0.050). The relative cost effectiveness of each arrival processing vaccina­tion program in the study population is therefore dependent on relative program cost.

Downloads

Published

2024-06-07

How to Cite

Hunsaker, B. D., McMullen, C. A., Stamm, C. G., Perrett, T., Hannon, S. J., Bryant, L. K., & Booker, C. W. (2024). A comparison of two multivalent modified live viral/bacterial combination vaccines in feedlot calves at ultra-high risk of developing undifferentiated fever/bovine respiratory disease. The Bovine Practitioner, 58(2), 23–33. https://doi.org/10.21423/bovine-vol58no2p23-33

Issue

Section

Research Article

Most read articles by the same author(s)

1 2 > >>