Systematic review of vaccine efficacy against Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni in North American cattle

  • Sarah F. Capik Texas A&M AgriLife Research, Texas A&M University System, Amarillo, Texas & Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas. WT Box 60998 Canyon, TX 79016
  • Heather K. Moberly Medical Sciences Library, University Libraries & Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, 202 Olsen Blvd 4462 TAMU, College Station, TX 77843
  • Robert L. Larson Department of Clinical Sciences, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506
Keywords: bovine respiratory disease, vaccine, morbidity, mortality, lung lesions

Abstract

Bovine respiratory disease (BRD) continues to greatly affect beef, dairy, and veal production systems. Vaccination against the bacteria involved is common, yet questions remain regarding efficacy. The purpose of this review was to evaluate the evidence for effects of vaccinating United States or Canadian beef, dairy, or veal calves for Mannheimia haemolytica, Pasteurella multocida, or Histophilus somni on BRD-related morbidity, mortality, or postmortem lung lesions. Comprehensive searches were performed of MEDLINE, EMBASE, and CAB Abstracts via OVID. The Bovine Practitioner and references of relevant systematic reviews were searched by hand. Major commercial vaccine producers were queried for additional product information.
Peer-reviewed, published after 1979, full text available in English, performed in the US/Canada, control group included, sufficient evidence of randomization/blinding, and correct statistical methods were essential criteria for inclusion in the review. Five studies met the criteria. Of them, 1 investigated a H. somni and M. haemolytica vaccine in feeder calves, 1 studied M. haemolytica vaccination in feeder calves, 1 evaluated a different commercially available M. haemolytica vaccine and 1 experimental M. haemolytica vaccine in young Holstein calves, and 1 investigated multiple vaccines for P. multocida or M. haemolytica or combinations thereof in nursing beef calves. There are too few repeated studies on comparable populations to support further analysis of BRD bacterial vaccine efficacy in North American cattle.

Published
2021-12-31
How to Cite
Capik, S. F., Moberly, H. K., & Larson, R. L. (2021). Systematic review of vaccine efficacy against Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni in North American cattle. The Bovine Practitioner, 55(2), 125-133. https://doi.org/10.21423/bovine-vol55no2p125-133
Section
Articles