Effect of prepartum energy balance on neutrophil function following pegbovigrastim treatment in periparturient cows
Keywords:periparturient, undernutrition, neutrophil
Treatment with granulocyte colony stimulating factor (GCSF) increases neutrophil (PMN) count and enhances PMN function in the periparturient cow. It was hypothesized that prepartum undernutrition might reduce the effect of a commercial recombinant bovine G-CSF product (pegbovigrastim; Imrestor (IMR), Elanco) on PMN count and function. Hence the objective of this study was to test the effect of undernutrition for 1 month prior to calving on the response to IMR.