Pegbovigrastim affected gene expression in neutrophils of transition cows indicating increased neutrophil function

Authors

  • Axel Heiser AgResearch, Hopkirk Research Institute, Palmerston North, 4442, New Zealand
  • Stephen LeBlanc Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1 Canada
  • Paul Rapnicki Elanco Animal Health, Greenfield, IN 46140
  • Scott McDougall Cognosco, AnexaFVC, Morrinsville, 3300, New Zealand

DOI:

https://doi.org/10.21423/aabppro20173392

Keywords:

transition cows, granulocyte colony stimulating factor, neutrophil, prepartum, under-nutrition

Abstract

Treatment of transition cows with granulocyte colony stimulating factor (G-CSF) has been shown to increase neutrophil count and function. It was hypothesized that prepartum under-nutrition might reduce the effect of a commercial recombinant bovine G-CSF product (pegbovigrastim; Imrestor, Elanco). Hence this study was undertaken to test the effect of under-nutrition and pegbovigrastim treatment on gene expression in neutrophils.

Cover image of the 50th Conference Proceedings: Text of "AABP Annual Conference" with the AABP logo superimposed over an interlocking 50. Yellow background.

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Published

2017-09-14

Issue

2017

Section

Posters

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