Liver tolerance as a mechanism for the development of BVDV persistent infection

Authors

  • S. E. Morarie Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007
  • N. P. Smirnova Animal Reproductive and Biotechnology Laboratory, Colorado State University, Ft. Collins, CO 80523
  • T. R. Hansen Animal Reproductive and Biotechnology Laboratory, Colorado State University, Ft. Collins, CO 80523
  • J. Mediger Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007
  • L. Braun Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007
  • C. C. L. Chase Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007

DOI:

https://doi.org/10.21423/aabppro20123957

Keywords:

Bovine viral diarrhea virus, BVDV, hepatitis C, persistent infection, fetal liver, liver tolerance

Abstract

Bovine viral diarrhea virus (BVDV) is a member of the pestivirus group of the Flavivirus family that also includes hepatitis C virus. Infection of a pregnant cow with BVDV from 40 to 120 days of gestation may result in persistent infection (PI) of the fetus with BVDV. In pregnant cows, BVDV infects the cells of the placenta and crosses into fetal circulation. Persistently infected calves have been recognized as the major reservoir for BVDV; therefore, identification and removal of PI calves are the focus of BVDV eradication efforts. The objective of this study was to evaluate the association of the fetal liver and liver tolerance with the development of PI with BVDV.

Cover image of the 45th Conference Proceedings: Three black-and-white cows lounge in a spring field. Yellow background.

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Published

2012-09-20

Issue

2012

Section

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