Comparing Cytopathic and Noncytopathic Bovine Viral Diarrhea Virus (BVDV) Vaccines

Antigen Trafficking Increased to Mucosal Surfaces with Noncytopathic Vaccines

Authors

  • C. C. L. Chase Department of Veterinary Science, South Dakota State University, Brookings, SD
  • L. J. Braun Department of Veterinary Science, South Dakota State University, Brookings, SD
  • L. Holler Department of Veterinary Science, South Dakota State University, Brookings, SD
  • M. Spire Schering-Plough Animal Health, Elkhorn, NE

DOI:

https://doi.org/10.21423/aabppro20084468

Keywords:

Bovine viral diarrhea virus, BVDV, respiratory disease, reproductive disease, mucosal immunity, parenteral vaccines, noncytopathic, cytopathic

Abstract

Bovine viral diarrhea virus (BVDV) is a major pathogen of cattle causing severe respiratory and reproductive disease. Since BVDV infects through the oral-nasal route, increasing mucosal immunity should decrease BVDV infection and disease. This makes parenteral vaccines that can traffic antigens to mucosal lymphoid tissue more advantageous for generating mucosal immunity. This study was aimed at the distribution of bovine viral diarrhea virus (BVDV) in tissues following vaccination with one of three commercial vaccines: two vaccines containing cytopathic (CP) BVDV viruses and one vaccine containing noncytopathic (NCP) BVDV virus.

Cover image of the 41st Conference Proceedings: A herd of cattle standing in the field, framed by a cloudy sky. Yellow background.

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Published

2008-09-25

Issue

2008

Section

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